Predavanje prof dr. Gian Gaetano Tartaglie

Boris Rogelj | 1. 10. 2024

Pozdravljeni,

Vabljeni na predavanje prof dr. Gian Gaetano Tartaglie iz Italijanskega Inštituta za Tehnologijo, Genova. Prof. Tartaglia se ukvarja z računalniškimi in biokemičnimi raziskavami omrežij proteinov in RNA in je dobitnik dveh ERC projektov.

Naslov predavanja je »Deciphering Scaffolding Roles on non-coding RNAs in Protein Condensation«. Povzetek spodaj.

Predavanje bo potekalo v četrtek, 3 oktobra 2024 ob 11:00 v seminarski sobi B220 na Institutu »Jožef Stefan«.

Lep pozdrav,

Boris Rogelj

Deciphering Scaffolding Roles on non-coding RNAs in Protein Condensation

We will explore the integration of computational and experimental strategies to unravel the complex interaction webs involving XIST [1] and RNAs associated with neurodevelopmental disorders such as Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) [2], as well as neurodegenerative diseases, including Parkinson’s and Amyotrophic Lateral Sclerosis (ALS) [3]. Our examination centers on the mechanisms that facilitate harmful liquid-to-solid phase transitions within cells. Highlighting the seminal discovery that non-coding RNAs function as scaffolds for protein-RNA interactions [4], our research has spotlighted specific transcript attributes critical for forming extensive RNA-protein complexes and instigating phase separation [5]. This knowledge is fundamental for comprehending cellular behaviors, especially regarding viral infection mechanisms [6]. Most importantly, our advancements in engineering synthetic RNAs to modify the condensation characteristics of proteins implicated in ALS represent a pivotal progression in our efforts to mitigate these debilitating conditions [7]. New data on RNA aptamers will be discussed.

  1. Cerase, A. et al. Nature Structural & Molecular Biology volume 29, 183 (2022) and 26, 331 (2019).
  2. Cid-Samper, F. et al. Cell Reports 25, 3422-3434.e7 (2018).
  3. Rupert et al. Nucleic Acids Research, Volume 51, 21, 27 (2023).
  4. De Groot, N. S. et al. Nature Communications 10, 3246 (2019).
  5. Vandelli, A. et al. Nucleic Acids Research 48, 11270 (2020).
  6. Giambruno, R, Zacco E. et al. Mol Ther Nucleic Acids 34 (2023).
  7. Zacco et al. Nature Communications, 3306 (2022).

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